Brands

Frontline Plus vs Advantage II

Compare Frontline Plus Spot-On to Advantage II Spot-On

Topical treatments, also known as spot-on treatments, remain a popular way to treat dogs and cats for fleas, ticks and other parasites.

Frontline Plus and Advantage II both provide monthly protection against fleas at all life stages, including killing eggs and larvae before they can develop into adult fleas. They also kill ticks and control lice infestations.

Frontline Plus is for use only on dogs and cats over 8 weeks of age. Advantage II may be used on dogs as young as 7 weeks and cats from 8 weeks of age.

Please ensure that you have the correct product for your pet’s body weight. It is important the treatment is only used on the animal is it intended for – Frontline Plus for dogs and Advantage II for dogs must not be used on cats.

Top tip: Fleas and ticks can carry nasty diseases, but protecting your pet doesn’t need to be difficult. Use our comparison chart to weigh up the pros and cons of the most popular products.


Kills Fleas
Repels Fleas	-	-
Kills Flea Eggs and Larvae
Kills Ticks
Repels Ticks	-	-
Kills and/or Repels Mosquitoes		-
Other Parasites	Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation	Treats and controls lice infestations
Safe for Pregnant or Nursing Pets
When does it starts working	Kills fleas within 12 hours and ticks within 48 hours	Kills fleas within 12 hours
Application	Topical	Topical
Active Ingredient(s)	Fipronil , S-methoprene	Imidacloprid, Pyriproxyfen
Dosage	Monthly	Monthly